참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 1-Methyl-1H-benzimidazol-6-amine | HCID 13680283 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 3-Methyl-4-bromo-5-aminobenzimidazole | HCID 12968452 | 35% |
반응 단계
To a solution of 3-methyl-5-aminobenzimidazole (0.27 g, 1.8 mmol) in 10 ml of AcOH was added Br2 (0.10 ml). The reaction mixture was stirred for 1 h at 25° C. and concentrated in vacuo, yielding an oil which was subjected to column chromatography (NH3 sat'd 3% MeOH/CHCl3) to yield 0.14 g (0.62 mmol, 35%) of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06316637B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_11 |
|---|
| ORD ID | ord-df82cdfd8d904547af74871b1b81e30c |
|---|
| 출처 메모 | uspto-grants-2001_11 |
|---|
