Bromine → HCID 178432201, 화합물
반응식
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[Br:12]Br>CC(O)=O>[CH3:1][C:2]1[NH:3][C:4]2[C:10]([Br:12])=[C:9]([NH2:11])[CH:8]=[CH:7][C:5]=2[N:6]=1참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of 0.9 g (6.1 mmol) of 2-methyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.16 ml of Br2 (3.1 mmol) dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo and purified on silica gel column chromatography (20% Isopropanol/EtOAC) to yield 0.56 g (2.5 mmol, 41%) of the desired product.
후처리
- customresulting
- customreaction mixture
- customReaction mixture
- concentrationwas concentrated in vacuo
- custompurified on silica gel column chromatography (20% Isopropanol/EtOAC)
출처 및 근거
- ORD 기록
- ord-a5e972421d32405c80f8d552a3f68e86
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06316637B1
반응 노트
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