참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 2-Isopropyl-1H-benzo[d]imidazol-5-amine | HCID 820749 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | HCID 178439939 | HCID 178439939 | 95% |
반응 단계
To a solution of 0.95 g (5.4 mmol) of 2-isopropyl-5-aminobenzimidazole in 50 ml of AcOH was added 0.19 ml (3.7 mmol) of Br2 dropwise and resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuc and purified on silica gel column chromatography (5% MeOH/EtOAC) to yield 0.89 g (3.5 mmol, 95%) of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06316637B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_11 |
|---|
| ORD ID | ord-20e9df3ce9f64331b10752d79890c388 |
|---|
| 출처 메모 | uspto-grants-2001_11 |
|---|
