Benzyl Bromide → HCID 18355353, 화합물

HRID 429648노트

반응식

HRID 429648 반응식
[CH:1]([C:3]1[C:11]2[C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[NH:5][CH:4]=1)=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH2:21](Br)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CN(C)C=O.C(OCC)(=O)C.O>[CH:1]([C:3]1[C:11]2[C:10]([C:12]([O:14][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[NH:5][CH:4]=1)=[O:2]

참가 물질

7

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 219013933-Formyl-1H-indole-4-carboxylic acid

생성물 1

HCID 18355353HCID 18355353, 화합물수율 90.3%

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a suspension of 3-formylindole-4-carboxylic acid (390 mg) and potassium carbonate (285 mg) in N,N-dimethylformamide (10 ml) was added benzyl bromide (353 mg) at ambient temperature and the mixture was stirred for 4 hours. The resulting mixture was diluted with ethyl acetate and water, then the layers were separated. The organic layer was washed with brine, dried over magnesium sulfate and concentrated in vacuo. The residual solid was triturated with diethyl ether:n-hexane (1:6) to give benzyl 3-formylindole-4-carboxylate (520 mg).

후처리

  1. customthe layers were separated
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residual solid was triturated with diethyl ether:n-hexane (1:6)

출처 및 근거

ORD 기록
ord-3dd551704da64c66bc87e665d4356671
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316482B1

반응 노트

불러오는 중…