N,N-Dimethylethylenediamine → 2-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole
반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH2:18].C(=O)(O)[O-].[Na+]>>[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH:18][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and N,N-dimethylethylenediamine (2 ml) were stirred at 80° C. for 8 hours. The reaction mixture was poured into saturated sodium bicarbonate aqueous solution and extracted with a mixture of chloroform and methanol. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The resiude was washed with diisopropyl ether to give 2-[[2-(dimethylamino)ethyl]amino]-4-nitro-1H-benzimidazole (113 mg).
후처리
- extractionextracted with a mixture of chloroform and methanol
- washThe organic layer was washed with brine
- dry with materialdried over magnesium sulfate
- customevaporated in vacuo
- washThe resiude was washed with diisopropyl ether
출처 및 근거
- ORD 기록
- ord-717ff083e89c4fddb7799ab63eab60f0
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06316482B1
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