참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,2-Dibromoethane | HCID 7839 | — |
| 반응물 | 3-Bromo-2-methyl-1-propene | HCID 357785 | — |
| 반응물 | 5-Bromo-2,3-dihydro-1-benzofuran | HCID 2776159 | — |
| 반응물 | Magnesium | HCID 5462224 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-(2-Methylallyl)-2,3-dihydrobenzofuran | HCID 18352878 | 99% |
반응 단계
A solution of 5-bromo-2,3-dihydrobenzofuran (50 grams, 0.251 mole), and 1,2-dibromoethane (2.2 ml) in tetrahydrofuran (250 ml) was added dropwise to a stirred suspension of magnesium turnings (7.5 grams, 0.31 gram-atoms) in tetrahydrofuran (50 ml) over a period of 45 minutes. During the addition the reaction temperature was maintained at 30° C. The solution was cooled in an ice-bath and 3-bromo-2-methylpropene was added all at once. After stirring overnight, the reaction was quenched with cold 2% hydrochloric acid and the mixture was extracted with ether. Evaporation of solvent gave 5-(2-methylallyl)-2,3-dihydrobenzofuran as an oil (43.4 grams, 99%). M+ 174.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06319920B1 |
|---|
| 출처 데이터셋 | uspto-grants-2001_11 |
|---|
| ORD ID | ord-a45ae6faff8c4257abb268f24372f7f0 |
|---|
| 출처 메모 | uspto-grants-2001_11 |
|---|
