Potassium cyanate → N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(1-aminocarbonylpiperidin-4-ylmethyl)amine

HRID 429830노트

반응식

HRID 429830 반응식
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([N:13]([CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)[CH2:14][CH3:15])[CH3:12])=[CH:6][CH:5]=1.[O-:23][C:24]#[N:25].[K+]>O>[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]([N:13]([CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([C:24]([NH2:25])=[O:23])[CH2:19][CH2:18]2)[CH2:14][CH3:15])[CH3:12])=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 11378442Potassium cyanateHCID 18352897N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine hydrochloride

생성물 1

HCID 18352825N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(1-aminocarbonylpiperidin-4-ylmethyl)amine수율 77.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(piperidin-4-ylmethyl)amine hydrochloride (0.42 grams, 1.16 mmole) and potassium cyanate (1.5 grams, 18.5 mmole) in water (5 ml) was heated under reflux for about 20 minutes. The white solid which formed upon cooling was collected and recrystallized from chloroform/hexane to give N-[2-(4-methoxyphenyl)-1-methylethyl]-N-ethyl-(1-aminocarbonylpiperidin-4-ylmethyl)amine (0.3 grams, 77%), m.p. 104-10° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for about 20 minutes
  3. customThe white solid which formed
  4. temperatureupon cooling
  5. customwas collected
  6. customrecrystallized from chloroform/hexane

출처 및 근거

ORD 기록
ord-4b7bf7587c4d4c43a61ba5b87f1779a9
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06319920B1

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