2,4-Di-tert-butylphenol → 2-Bromo-4,6-di-tert-butylphenol

HRID 429945노트

반응식

HRID 429945 반응식
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[Br:16]Br>>[Br:16][C:7]1[CH:8]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15]

참가 물질

3

반응물 2

HCID 73112,4-Di-tert-butylphenolHCID 24408Bromine

생성물 1

HCID 5198222-Bromo-4,6-di-tert-butylphenol수율 91.8%

실험 절차

To a solution of 2,4-di-t-butylphenol (Aldrich, 2.0 g, 9.7 mmol) in 2 ml of HOAC was added Br2 (0.5 ml, 9.7 mmol). The reaction mixture was stirred at room temperature for 12 hours. Solvent was removed under reduced pressure and the residue was purified by column chromatography (ethyl acetate/hexane 1/20) to yield the desired product (2.54 g) as a white solid.

후처리

  1. customSolvent was removed under reduced pressure
  2. customthe residue was purified by column chromatography (ethyl acetate/hexane 1/20)

출처 및 근거

ORD 기록
ord-7fed9cd228f34ef19a46051c6ee2e031
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06320047B1

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