Imidazole → 1-{4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzoyl}imidazole

HRID 430026노트

반응식

HRID 430026 반응식
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][O:9][C:10]([NH:12][CH2:13][C:14]2[CH:22]=[CH:21][C:17]([C:18](Cl)=[O:19])=[CH:16][CH:15]=2)=[O:11])[CH:3]=1.[NH:23]1[CH:27]=[CH:26][N:25]=[CH:24]1>O1CCCC1>[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][O:9][C:10]([NH:12][CH2:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([N:23]3[CH:27]=[CH:26][N:25]=[CH:24]3)=[O:19])=[CH:16][CH:15]=2)=[O:11])[CH:3]=1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 45358729HCID 45358729, 화합물

생성물 1

HCID 98191321-{4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzoyl}imidazole수율 55.4%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1 g (2.9 mmole) of 4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzoyl chloride hydrochloride was added to a tetrahydrofuran (10 ml) solution including 0.6 g (8.8 mmole) of imidazole, followed by stirring for 1 hour. A deposited imidazole hydrochloride was removed by filtration, and the reaction solution was then concentrated. Ethyl acetate and water were added to the solution to carry out partition, and the organic layer was then treated in an ordinary manner to obtain 0.54 g (yield: 55%) of 1-{4-[N-(pyridin-3-ylmethoxycarbonyl)aminomethyl]benzoyl}imidazole.

후처리

  1. customA deposited imidazole hydrochloride was removed by filtration
  2. concentrationthe reaction solution was then concentrated
  3. additionEthyl acetate and water were added to the solution
  4. customto carry out partition
  5. additionthe organic layer was then treated in an ordinary manner

출처 및 근거

ORD 기록
ord-2af7bd0a26914cfe849a76bd1132a9de
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06320078B1

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