Cadaverine → 2-(5-Aminopent-1-ylamino)-4-methoxyquinoline

HRID 430064

반응식

HRID 430064 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].Cl[C:9]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.CO.N>ClCCl>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:9]1[CH:18]=[C:17]([O:19][CH3:20])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

참가 물질

5

반응물 3

HCID 273CadaverineHCID 123691662-Chloro-4-methoxyquinolineHCID 21705897Ammonia methanol

생성물 1

HCID 183537442-(5-Aminopent-1-ylamino)-4-methoxyquinoline

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared by an analogous procedure to that described in example 1a from 1,5-diaminopentane (5 g, 49 mmol) and 2-chloro-4-methoxyquinoline (0.93 g, 4.8 mmol) to yield, after chromatography over silica gel eluting with an increasing concentration of 9:1 methanol/ammonia in dichloromethane, a cream coloured solid (30%). δH (CDCl3) 1.0-1.8 (8H, envelop), 2.72 (2H, t), 3.4-3.5 (2H, m), 3.97 (3H, s), 4.6-4.79 (1H, m), 5.94 (1H, m), 7.18 (1H, t), 7.51 (1H, t), 7.60 (1H, d), 7.96 (1H, d). MS (ES+) 260 (90%) MH+.

후처리

  1. customto yield

출처 및 근거

ORD 기록
ord-ad381287de1e4094a66e1bb4888d6aa6
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06320051B1

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