Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethyl-4-(4-nitrophenyl)piperazine → 4-(4-Ethylpiperazin-1-yl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethyl-4-(4-nitrophenyl)piperazine | HCID 2857549 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-(4-Ethylpiperazin-1-yl)aniline | HCID 936738 | 98% |
반응 단계
A suspension of 1-ethyl-4-(4-nitro-phenyl)-piperazine (Step 1.10) (6.2 g, 26.35 mmol) and Raney nickel (2 g) in MeOH (120 mL) was stirred for 7 h at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 5.3 g of the title compound as a violet solid: ESI-MS: 206.1 [M+H]+; TLC: Rf=0.15 (DCM/MeOH+1% NH3aq, 9:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536175B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-fb5437eac61e4a59b568d9395c71ef5c |
| 출처 메모 | uspto-grants-2013_09 |