Methyl 3-bromo-2,4,5-trifluorobenzoate → Methyl 3-cyano-2,4,5-trifluoro-benzoate

HRID 430591노트

반응식

HRID 430591 반응식
Br[C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6].[Cu][C:16]#[N:17]>CN(C)C=O>[C:16]([C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6])#[N:17]

참가 물질

4

반응물 2

HCID 18459836Methyl 3-bromo-2,4,5-trifluorobenzoateHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 18417526Methyl 3-cyano-2,4,5-trifluoro-benzoate수율 61.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 269 g of methyl 3-bromo-2,4,5-trifluorobenzoate, 108 g of copper(I) cyanide and 400 ml of dimethylformamide is heated under reflux for 5 hours. All volatile components are distilled off in vacuo. Fractional distillation of the resulting mixture gives 133 g of the title compound.

후처리

  1. temperatureis heated
  2. temperatureunder reflux for 5 hours
  3. distillationAll volatile components are distilled off in vacuo
  4. distillationFractional distillation of the resulting mixture

출처 및 근거

ORD 기록
ord-88c4248f374b4852b39ecf0afe36429e
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323213B1

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