Oxalyl chloride → 3-Cyano-2,4,5-trifluoro-benzoyl chloride

HRID 430593노트

반응식

HRID 430593 반응식
[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6](O)=[O:7])#[N:2].C(Cl)(=O)C([Cl:18])=O>CN(C)C=O.C(Cl)Cl>[C:1]([C:3]1[C:4]([F:14])=[C:5]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:6]([Cl:18])=[O:7])#[N:2]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 18417533195532-64-0

생성물 1

HCID 186187613-Cyano-2,4,5-trifluoro-benzoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

111 g of 3-cyano-2,4,5-trifluoro-benzoic acid, 84 g of oxalyl chloride and a few drops of dimethylformamide in 930 ml of dry methylene chloride are stirred at room temperature for 5 hours. The reaction mixture is concentrated by evaporation and the residue is distilled in vacuo.

후처리

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. distillationthe residue is distilled in vacuo

출처 및 근거

ORD 기록
ord-2b89adf6c891449e8baa063d8a6962d8
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323213B1

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