1,1'-Carbonyldiimidazole → Ethyl 1-(Benzofuran-3-ylacety)-4-piperidinecarboxylate

HRID 430600노트

반응식

HRID 430600 반응식
C(N1C=CN=C1)(N1C=CN=C1)=O.[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([CH2:22][C:23]([OH:25])=O)=[CH:14]1.[NH:26]1[CH2:31][CH2:30][CH:29]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:28][CH2:27]1>ClCCl>[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([CH2:22][C:23]([N:26]2[CH2:31][CH2:30][CH:29]([C:32]([O:34][CH2:35][CH3:36])=[O:33])[CH2:28][CH2:27]2)=[O:25])=[CH:14]1

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 70770Ethyl 4-piperidinecarboxylateHCID 27629402-(1-Benzofuran-3-yl)acetic acid

생성물 1

HCID 15512383Ethyl 1-(Benzofuran-3-ylacety)-4-piperidinecarboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

22 g of carbonyldiimidazole are added in portions to 23.9 g of benzofuran-3-ylacetic acid in 250 ml of dichloromethane. When the evolution of gas has stopped, the reaction mixture is stirred for 1 hour and then 21 ml of ethyl piperid-4-ylcarboxylate are added dropwise. After 12 hours' stirring at room temperature, the reaction mixture is washed with 1N sodium hydroxide solution and then with 1N hydrochloric acid. After decanting and drying, concentration under reduced pressure enables the expected product to be isolated.

후처리

  1. stirringAfter 12 hours' stirring at room temperature
  2. washthe reaction mixture is washed with 1N sodium hydroxide solution
  3. customAfter decanting
  4. customdrying
  5. concentrationconcentration under reduced pressure
  6. customto be isolated

출처 및 근거

ORD 기록
ord-519d9fcff93846d8911cd7f7fac2334c
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323217B2

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