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Methylamine → 1-(Benzofuran-3-ylacetyl)-n-methyl-4-piperidinecarboxamide

HRID 430602
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인쇄 미리보기

반응식

HRID 430602 반응식
[C:1](N1C=CN=C1)([N:3]1C=CN=C1)=O.[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([CH2:22][C:23]([N:25]2[CH2:30][CH2:29][CH:28]([C:31]([OH:33])=O)[CH2:27][CH2:26]2)=[O:24])=[CH:14]1.CN>ClCCl.O>[O:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[C:15]([CH2:22][C:23]([N:25]2[CH2:30][CH2:29][CH:28]([C:31]([NH:3][CH3:1])=[O:33])[CH2:27][CH2:26]2)=[O:24])=[CH:14]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 6329MethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 155123841-(Benzofuran-3-ylacetyl)-4-piperidinecarboxlic acid

생성물 1

HCID 155123851-(Benzofuran-3-ylacetyl)-n-methyl-4-piperidinecarboxamide

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane
용매

실험 절차

19 g of carbonyldiimidazole are added in portions to 33 g of the product obtained in Step B in 350 ml of dichloromethane. When the evolution of gas has stopped, the reaction mixture is stirred for 1 hour at room temperature and then a stream of methylamine is circulated through it. After 12 hours' stirring, the mixture is diluted with water, decanted, washed with 1N sodium hydroxide solution and then with 1N hydrochloric acid, decanted, dried and evaporated, enabling the expected product to be isolated.

후처리

  1. stirringAfter 12 hours' stirring
  2. customdecanted
  3. washwashed with 1N sodium hydroxide solution
  4. customwith 1N hydrochloric acid, decanted
  5. customdried
  6. customevaporated
  7. customto be isolated

출처 및 근거

ORD 기록
ord-0b9e071e1d9f42e5921596c792080760
출처 데이터셋
uspto-grants-2001_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06323217B2

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