2-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole → 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-ylamine

HRID 43061노트

반응식

HRID 43061 반응식
[N+:1]([C:4]1[N:5]([CH2:9][O:10][CH2:11][CH2:12][Si:13]([CH3:16])([CH3:15])[CH3:14])[CH:6]=[CH:7][N:8]=1)([O-])=O>[Pd].CO>[CH3:14][Si:13]([CH3:16])([CH3:15])[CH2:12][CH2:11][O:10][CH2:9][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[NH2:1]

참가 물질

4

반응물 1

HCID 143583852-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

생성물 1

HCID 669145481-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-ylamine수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of 2-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole (Step 14.3) (1.84 g, 7.57 mmol) and palladium on carbon (200 mg) in MeOH (30 mL) was stirred for 40 min at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 1.55 g of the title compound: ESI-MS: 214.1 [M+H]+; tR=3.26 min (System 1).

후처리

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1c4ad95aea094add9567a8356d391640
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536175B2

반응 노트

불러오는 중…