Ammonium Hydroxide → 4-Bromo-5-nitroisoquinoline

HRID 430615

반응식

HRID 430615 반응식
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[N+:12]([O-])([O-:14])=[O:13].[K+].[OH-].[NH4+]>S(=O)(=O)(O)O>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[N+:12]([O-:14])=[O:13])[CH:5]=[N:4][CH:3]=1

참가 물질

5

반응물 3

HCID 14923Ammonium HydroxideHCID 24434Potassium NitrateHCID 737434-Bromoisoquinoline

생성물 1

HCID 2712804-Bromo-5-nitroisoquinoline

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

Add 11 g of 4-bromoisoquinoline to 45 ml of sulphuric acid, followed, dropwise, by a solution of 9.1 g of potassium nitrate in 45 ml of sulphuric acid whilst cooling in an ice-bath. The reaction mixture is stirred at room temperature for 2 hours 30, before being poured onto ice. After the resulting solution has been rendered basic with ammonium hydroxide, the crystals are filtered off, washed and dried to yield the expected product.

후처리

  1. additionbefore being poured onto ice
  2. filtrationthe crystals are filtered off
  3. washwashed
  4. customdried

출처 및 근거

ORD 기록
ord-b2b2a7b55cf246a59559dfaa0a888bd2
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323217B2

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