Ethanol → Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate

HRID 430696노트

반응식

HRID 430696 반응식
[CH2:1]([O:3][C:4](=[O:21])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=2)[CH2:8][CH2:7]1)[CH3:2].C(O)C>O1CCCC1.[Pt]=O>[Cl:20][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][C:16]=1[Cl:19])[CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:21])[CH2:11][CH2:10]1

참가 물질

5

반응물 2

HCID 702EthanolHCID 18351421HCID 18351421, 화합물

생성물 1

HCID 10758769Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate수율 99.5%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl[1-(3,4-dichlorobenzyl)piperidin-4-ylidene]acetate (3.9 g, 11.9 mmol) dissolved in tetrahydrofuran (25 ml) and ethanol (25 ml) was subjected to hydrogenation over platinum oxide (0.1 g) at ambient temperature and atmospheric pressure. The reaction mixture was filtered through a celite pad and concentrated in vacuo to give ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate (3.91 g) as a semi-solid.

후처리

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5e889fefb43d4f9d9ebaf96dc09d9961
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323223B1

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