1-Naphthaleneboronic acid → 8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)phenyl]-amide

HRID 43078

반응식

HRID 43078 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:15]1([C:25]2[C:34]3[N:33]=[CH:32][CH:31]=[N:30][C:29]=3[C:28]([C:35](O)=[O:36])=[CH:27][CH:26]=2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][CH:16]=1.C1(B(O)O)C2C(=CC=CC=2)C=CC=1>C(Cl)Cl.CO>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:14]=[CH:13][C:11]([NH:12][C:35]([C:28]3[C:29]4[N:30]=[CH:31][CH:32]=[N:33][C:34]=4[C:25]([C:15]4[C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[CH:18]=[CH:17][CH:16]=4)=[CH:26][CH:27]=3)=[O:36])=[CH:10][CH:9]=2)[CH2:6][CH2:7]1

참가 물질

5

반응물 3

HCID 2545321-Naphthaleneboronic acidHCID 7372534-(4-Methylpiperazin-1-yl)anilineHCID 669146068-Naphthalen-1-yl-quinoxaline-5-carboxylic acid

생성물 1

HCID 445153558-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)phenyl]-amide

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

The title compound was prepared in analogy to the procedure described in in Step 14.1 but stirring the reaction mixture overnight and using 4-(4-methylpiperazin-1-yl)-aniline (WO2006000420) and 8-naphthalen-1-yl-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 1-naphtylboronic acid in Step 1.4. Title compound: ESI-MS: 474.0 [M+H]+; tR=4.34 min (System 1); TLC: Rf=0.45 (DCM/MeOH/NH3aq, 94:5:1).

후처리

  1. customThe title compound was prepared in analogy to the procedure
  2. customThe latter compound was synthesized

출처 및 근거

ORD 기록
ord-cb48339784fb41b5b6cdbf7ed92c34d3
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536175B2

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