O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 59292849, 화합물

HRID 43086

반응식

HRID 43086 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:15][C:16]([C:18]3[C:19]4[N:20]=[CH:21][CH:22]=[N:23][C:24]=4[C:25](C4C(Cl)=C(OC)C=C(OC)C=4Cl)=[CH:26][CH:27]=3)=[O:17])=[N:13][CH:14]=2)[CH2:4][CH2:3]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C(N1CCN(C2C=C(NC(C3C4N=CC=NC=4C([C:89]4[C:98]5[C:93](=[CH:94][CH:95]=[CH:96][CH:97]=5)[CH:92]=[N:91][CH:90]=4)=CC=3)=O)C=CC=2)CC1)C>C(Cl)Cl.CO>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[CH:11][C:12]([NH:15][C:16]([C:18]3[C:19]4[N:20]=[CH:21][CH:22]=[N:23][C:24]=4[C:25]([C:89]4[C:98]5[C:93](=[CH:94][CH:95]=[CH:96][CH:97]=5)[CH:92]=[N:91][CH:90]=4)=[CH:26][CH:27]=3)=[O:17])=[N:13][CH:14]=2)[CH2:4][CH2:3]1

참가 물질

5

반응물 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 445147468-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(4-methyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amideHCID 445156698-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide

생성물 1

HCID 59292849HCID 59292849, 화합물

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture for 17 h at rt, using 2 equiv of 5-(4-methyl-piperazin-1-ylmethyl)pyridin-2-ylamine hydrochloride (Example 31), TBTU (2 equiv) and 8-isoquinolin-4-ylquinoxaline-5-carboxylic acid (Example 52). Title compound: ESI-MS: 490.0 [M+H]+; tR=2.21 min (System 1); TLC: Rf=0.17 (DCM/MeOH, 9:1).

후처리

  1. customThe title compound was prepared in analogy to the procedure

출처 및 근거

ORD 기록
ord-9abaedaa4ed64f2dba2d7ea89527d9f2
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536175B2

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