4-(4-Ethylpiperazin-1-yl)aniline → 8-(2-Chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

HRID 43092

반응식

HRID 43092 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].C(N1CCN(C2C=C(N[C:31]([C:33]3[C:34]4[N:35]=[CH:36][CH:37]=[N:38][C:39]=4[C:40]([C:43]4[CH:48]=[C:47]([O:49][CH3:50])[CH:46]=[CH:45][C:44]=4[Cl:51])=[CH:41][CH:42]=3)=[O:32])C=CC=2)CC1)C>>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:15]=[CH:14][C:12]([NH:13][C:31]([C:33]3[C:34]4[N:35]=[CH:36][CH:37]=[N:38][C:39]=4[C:40]([C:43]4[CH:48]=[C:47]([O:49][CH3:50])[CH:46]=[CH:45][C:44]=4[Cl:51])=[CH:41][CH:42]=3)=[O:32])=[CH:11][CH:10]=2)[CH2:7][CH2:8]1)[CH3:2]

참가 물질

3

반응물 2

HCID 9367384-(4-Ethylpiperazin-1-yl)anilineHCID 445159808-(2-Chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)-phenyl]-amide

생성물 1

HCID 445162808-(2-Chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid [4-(4-ethyl-piperazin-1-yl)-phenyl]-amide

실험 절차

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 4-(4-ethylpiperazin-1-yl)-aniline (Step 1.9) and 8-(2-chloro-5-methoxy-phenyl)quinoxaline-5-carboxylic acid (Example 63). Title compound: ESI-MS: 502.1 [M]+; tR=3.50 min (System 3).

후처리

  1. customThe title compound was prepared in analogy to the procedure

출처 및 근거

ORD 기록
ord-067e088f15f4434d9a60c46db78b0ff6
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536175B2

연결된 노트

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