Trifluoroacetic acid → (Pyrole-2-carbonyl)-N-(benzyl)glycine

HRID 430947노트

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HRID 430947 반응식
C([O:5][C:6](=[O:23])[CH2:7][N:8]([C:16]([C:18]1[NH:19][CH:20]=[CH:21][CH:22]=1)=[O:17])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:16]([N:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][C:6]([OH:23])=[O:5])=[O:17]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acid2회HCID 70020108(Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester

생성물 1

HCID 18762404(Pyrole-2-carbonyl)-N-(benzyl)glycine수율 94.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

To a solution containing 2.85 g (9.01 mmol) of (Pyrrole-2-carbonyl)-N-(benzyl)glycine-t-butyl ester in 50 mL of anhydrous dichloromethane cooled to 0° C. was added 25 mL of TFA dropwise. After 90 minutes an additional 25 mL of TFA was added and allowed to stir for 30 minutes. The mixture was evaporated in vacuo to afford 2.19 g of (Pyrole-2-carbonyl)-N-(benzyl)glycine as a tan solid. FAB MS[M+H]m/z; Calcd. 259, Found 259.

후처리

  1. customThe mixture was evaporated in vacuo

출처 및 근거

ORD 기록
ord-94024a8a88f04c5d86cca63fe6238153
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06656911B2

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