Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → N-methyl-1-(4-nitrophenyl)methanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Sodium chloride; water | HCID 57417360 | — |
| 생성물 | N-methyl-1-(4-nitrophenyl)methanamine | HCID 409440 | 97.2% |
반응 단계
A solution of p-nitrobenzylbromide (5.40 g, 25 mmol) in acetonitrile (60 ml) is added dropwise to a stirred solution of aqueous methylamine (65 mL, 40 wt. %, 0.75 mol) in acetonitrile (50 mL) at 0°. After stirring an additional 15 minutes, the solution is poured into brine and extracted 2× with dichloromethane. The combined organic layers are washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to give 4-(methylaminomethyl)nitrobenzene (4.04g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06656941B2 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-34d76e8d03e045edb910352de3dfe344 |
| 출처 메모 | uspto-grants-2003_12 |