Potassium Carbonate → Benzimidazole

반응식

Cl[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.BrCC(C1C(C)=C(SCC)C=CN=1)=O.C([O-])([O-])=O.[K+].[K+]>>[N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[NH:6][CH:2]=1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 785722-Chlorobenzimidazole

HCID 144215532-Bromoacetyl-4-ethylthio-3-methylpyridine

생성물 1

HCID 5798Benzimidazole

실험 절차

2-Chlorobenzimidazole is reacted with 2-bromoacetyl-4-ethylthio-3-methylpyridine in the presence of K2CO3 to give 2-chloro-1-[2-[4-ethylthio-3-methylpyridyl])-2-oxoethyl]benzimidazole. This is reacted with thiourea and treated with NH4OH to give 2-mercapto-1-(2-(2-(4-ethylthio-3-methylpyridyl))-2-oxoethyl)benzimidazole

출처 및 근거

ORD 기록: ord-39008d9572cc46a1a61451fb05242526
출처 데이터셋: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04725605

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