Sodium methanethiolate → 5-chloro-2-methylsulfanylindan-1-one

HRID 431300

반응식

HRID 431300 반응식
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:11])[CH:8]=2)[C:3]1=[O:12].[CH3:13][S-:14].[Na+]>C(O)C>[Cl:11][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[C:3](=[O:12])[CH:2]([S:14][CH3:13])[CH2:10]2

참가 물질

4

반응물 2

HCID 4378561Sodium methanethiolateHCID 113340692-Bromo-5-chloro-2,3-dihydro-1H-inden-1-one

생성물 1

HCID 99207715-chloro-2-methylsulfanylindan-1-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.98 g (4 mmol) of 2-bromo-5-chloroindan-1-one and 0.42 g (6 mmol) of sodium thiomethoxide were suspended in 5 ml of ethanol, treated in an ultrasonic bath for 30 minutes and then stirred at room temperature for 90 minutes. The reaction mixture was concentrated under reduced pressure and chromatographed on silica gel using toluene/ethyl acetate 10/1. The eluates were concentrated under reduced pressure, giving 5-chloro-2-methylsulfanylindan-1-one of melting point 90° C.

후처리

  1. additiontreated in an ultrasonic bath for 30 minutes
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customchromatographed on silica gel
  4. concentrationThe eluates were concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-85d7dcc5c4784dd09fe04f0ab3a0c3c0
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06657086B2

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