참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Piperazinone, 3,3-dimethyl- | HCID 211157 | 68.8% |
반응 단계
A solution of ethyl-2-bromoisobutyrate (24 mL, 161 mmol) in toluene (150 mL) was added to a mixture of ethylene diamine (70 mL, 1046 mmol, 6.5 equiv) and potassium carbonate (24.4 g, 177 mmol, 1.1 equiv) in toluene (150 mL). The reaction mixture was heated for 20 h at 115° C., cooled and filtered. The filtrate was concentrated and the residue triturated in Et2O to afford 14.2 g of the title compound as a yellow solid: ESI-MS: 129.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536175B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
|---|
| ORD ID | ord-b6f1359851554a6e8633af1cffc9717a |
|---|
| 출처 메모 | uspto-grants-2013_09 |
|---|
