Trimethylamine → 1,3-Dihydroxy-5-trimethylsiloxyadamantane

HRID 431418노트

반응식

HRID 431418 반응식
[OH:1][C:2]12[CH2:11][C:6]3([OH:12])[CH2:7][CH:8]([CH2:10][C:4]([OH:13])([CH2:5]3)[CH2:3]1)[CH2:9]2.CN(C)C.[CH3:18][Si:19](Cl)([CH3:21])[CH3:20]>C(Cl)Cl>[OH:1][C:2]12[CH2:11][C:6]3([O:12][Si:19]([CH3:21])([CH3:20])[CH3:18])[CH2:7][CH:8]([CH2:10][C:4]([OH:13])([CH2:5]3)[CH2:3]1)[CH2:9]2

참가 물질

5

반응물 3

HCID 1146TrimethylamineHCID 6397ChlorotrimethylsilaneHCID 98990221,3,5-Adamantanetriol

생성물 1

HCID 219307101,3-Dihydroxy-5-trimethylsiloxyadamantane

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

This 1,3,5-trihydroxyadamantane was dissolved in methylene chloride. To this solution were added a small amount of trimethylamine, and then an equimolar amount of trimethylsilyl chloride. Reaction was carried out at room temperature. The reaction product was partitioned by high performance liquid chromatography to obtain 1,3-dihydroxy-5-trimethylsiloxyadamantane.

후처리

  1. customReaction
  2. customwas carried out at room temperature
  3. customThe reaction product was partitioned by high performance liquid chromatography

출처 및 근거

ORD 기록
ord-609fd757932c4d9781e7d8b82ed4d6a3
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660450B2

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