2-Thiophenecarboxaldehyde → 1,3-Dimethyl-2-(2-thienyl)imidazolidine
반응식
[CH3:1][NH:2][CH2:3][CH2:4][NH:5][CH3:6].[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]=O>C1(C)C=CC=CC=1>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH3:6])[CH:12]1[C:8]1[S:7][CH:11]=[CH:10][CH:9]=1참가 물질
4
실험 절차
23.5 g (267 mmol) of N,N′-dimethylethylenediamine were dissolved in 300 ml of toluene and treated with 29.8 g (266 mmol) of thiophene-2-carbaldehyde. The clear mixture was refluxed for 4 hours using a Dean-Stark trap. After that time 4.9 ml of water had separated in the trap. After cooling, the solution was filtered and evaporated. The oily residue was destilled in vacuo. Yield: 45 g.
후처리
- temperatureThe clear mixture was refluxed for 4 hours
- customAfter that time 4.9 ml of water had separated in the trap
- temperatureAfter cooling
- filtrationthe solution was filtered
- customevaporated
출처 및 근거
- ORD 기록
- ord-1f9eeb3f89254766817b39ea5913bb0e
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06660728B2
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