Tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate → tert-butyl N-(2-(2-aminoethoxy)ethyl)-N-methylcarbamate

HRID 431610노트

반응식

HRID 431610 반응식
[N:1]([CH2:4][CH2:5][O:6][CH2:7][CH2:8][N:9]([CH3:17])[C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH2:5][O:6][CH2:7][CH2:8][N:9]([CH3:17])[C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15]

참가 물질

4

반응물 1

HCID 21093756Tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate

생성물 1

HCID 85823338tert-butyl N-(2-(2-aminoethoxy)ethyl)-N-methylcarbamate수율 100.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate (41.9 g, 170 mmol) in 600 mL of MeOH was treated with 2.5 g of 10% Pd on carbon and shaken under H2 (3 Kg/cm2) for 24 h. The solution was then filtered through a Celite pad and concentrated to give 37.2 g of crude tert-butyl 2-(2-aminoethoxy)ethyl(methyl)carbamate as a light yellow liquid.

후처리

  1. filtrationThe solution was then filtered through a Celite pad
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-416ba1e3ec2643cb8f50c17c7f8fddf7
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660747B2

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