Potassium Fluoride → 2-Cyano-3-fluoropyridine

HRID 431853

반응식

HRID 431853 반응식
[C:1]([C:3]1[C:8](Cl)=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2].[F-:10].[K+]>CN1CCCC1=O.C(OCC)(=O)C>[C:1]([C:3]1[C:8]([F:10])=[CH:7][CH:6]=[CH:5][N:4]=1)#[N:2]

참가 물질

5

반응물 2

HCID 522689Potassium FluorideHCID 8182583-Chloropyridine-2-carbonitrile

생성물 1

HCID 70604082-Cyano-3-fluoropyridine수율 50.1%

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

A solution of 2-cyano-3-chloropyridine (1 g, 7.22 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was treated with potassium fluoride (1.26 g, 21.68 mmol) and heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. Silica gel chromatography afforded 442 mg (50%) of 2-cyano-3-fluoropyridine.

후처리

  1. temperatureheated
  2. temperatureat reflux for 18 hours
  3. temperatureAfter cooling
  4. extractionextracted with water and brine

출처 및 근거

ORD 기록
ord-014da495d5b5402d8cbd5806a0c66b61
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660753B2

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