Water → 4-Amino-3-bromo-5-(trifluoromethoxy)benzoic acid

HRID 431873

반응식

HRID 431873 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13].[Br:16]Br.O>C(O)(=O)C>[NH2:1][C:2]1[C:3]([O:11][C:12]([F:13])([F:14])[F:15])=[CH:4][C:5]([C:6]([OH:8])=[O:7])=[CH:9][C:10]=1[Br:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 24408BromineHCID 27359514-amino-3-(trifluoromethoxy)benzoic Acid

생성물 1

HCID 219424074-Amino-3-bromo-5-(trifluoromethoxy)benzoic acid수율 57.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a solution of 4-amino-3-trifluoromethoxybenzoic acid (5 g, 22.6 mmoles) in acetic acid (50 mL), bromine(3.98 g, 24.9 mmoles) in acetic acid(10 mL) was added dropwise at room temperature. After the reaction mixture was kept stirring for one hour, water was added into the mixture. The solid was filtered and washed with water to give 4-amino-3-bromo-5-trifluoromethoxybenzoic acid (3.9 g, 54.9%).

후처리

  1. filtrationThe solid was filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-2ca0e522c37f40aeba58016934a2063d
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660753B2

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