Oxalyl chloride → 3-Cyano-5-fluoro-benzoic acid chloride
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]#[N:12])[CH:10]=1)[C:5](O)=[O:6].C(Cl)(=O)C([Cl:16])=O>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]#[N:12])[CH:10]=1)[C:5]([Cl:16])=[O:6]참가 물질
4
실험 절차
3-Fluoro-5-cyanobenzoic acid (2.5 g, 15.14 mmol) was treated with a solution of oxalyl chloride (30 mL of 2.5 M in dichloromethane, 75 mmol) and a catalytic amount of N,N-dimethylformamide. The reaction was stirred at ambient temperature for 2.5 hours. The excess oxalyl chloride was removed in vacuo to afford 3-fluoro-5-cyanobenzoyl chloride.
후처리
- customThe excess oxalyl chloride was removed in vacuo
출처 및 근거
- ORD 기록
- ord-31324f00a1f6494ba57a01cb85e76eef
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06660753B2
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