Dimethylformamide → 3,4,5-Trifluorobenzoyl chloride

HRID 431896

반응식

HRID 431896 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].C(Cl)(=O)C([Cl:16])=O.CN(C)C=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 8531543,4,5-Trifluorobenzoic acid

생성물 1

HCID 27770233,4,5-Trifluorobenzoyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3,4,5-Trifluorobenzoic acid (0.176 g, 1.0 mmol) in dichloromethane (1.5 mL) was treated with a solution of oxalyl chloride (1.5 mL of 2 M in dichloromethane, 3 mmol) and a catalytic amount of N,N-dimethylformamide. The reaction was stirred overnight at ambient temperature. The excess oxalyl chloride was removed in vacuo to afford 3,4,5-trifluorobenzoyl chloride.

후처리

  1. customThe excess oxalyl chloride was removed in vacuo

출처 및 근거

ORD 기록
ord-4b5b0fa67ece481b83ddb595cf6bd416
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660753B2

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