Lawesson's reagent → 3-Iodothiobenzamide

HRID 431990노트

반응식

HRID 431990 반응식
[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:20])=CC=1>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[S:20]

참가 물질

4

반응물 2

HCID 87949Lawesson's reagentHCID 2024253-Iodobenzamide

생성물 1

HCID 27593753-Iodothiobenzamide수율 99%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 3-iodobenzamide (500 mg, 2.0 mmol) in toluene (5 mL) was treated with Lawesson's reagent (404 mg, 1 mmol) and the mixture heated at reflux for 16 hours. After cooling, silica gel chromatography afforded 260 mg (99% yield) of 3-iodothiobenzamide, as a yellow solid.

후처리

  1. temperaturethe mixture heated
  2. temperatureat reflux for 16 hours
  3. temperatureAfter cooling

출처 및 근거

ORD 기록
ord-cbec41ecf5534e8aa214a381eb88e58f
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660753B2

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