Water → [(2R)-6-iodo-3,4-dihydro-2H-chromen-2-yl]methanol

HRID 432081

반응식

HRID 432081 반응식
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C@@H:7]([C:12](O)=[O:13])[CH2:6][CH2:5]2.B.C1COCC1.O.C([O-])(O)=O.[Na+]>C1COCC1>[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C@@H:7]([CH2:12][OH:13])[CH2:6][CH2:5]2

참가 물질

6

반응물 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 2723981Borane;tetrahydrofuranHCID 9966213(2R)-6-Iodochromane-2-carboxylic acid

생성물 1

HCID 9943850[(2R)-6-iodo-3,4-dihydro-2H-chromen-2-yl]methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
45 °C

실험 절차

To a solution of (2R)-6-iodo-3,4-dihydro-2H-chromene-2-carboxylic acid (Example 7, 19.5 mmol, 1.0 eq.) in THF (45 mL) at 10° C. was added dropwise a solution of borane-THF complex (1M in THF, 23.4 mmol, 1.2 eq). The resulting reaction mixture was stirred at 45° C. for 1.5 hours and was then cooled to 10° C. Next, water was added followed by saturated NaHCO3 solution. The resulting two-phase mixture was separated and the aqueous phase was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, concentrated to afford the product as a white solid in quantitative yield that was used without further purification. GC-MS m/z 290 (M+)

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas then cooled to 10° C
  3. customThe resulting two-phase mixture was separated
  4. extractionthe aqueous phase was extracted with ethyl acetate
  5. washThe combined organic extracts were washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9f9d4a6bdbcd444f8483b577369ce20a
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660752B2

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