Ethanol → Ethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

HRID 43230

반응식

HRID 43230 반응식
[CH2:1]([C:3]([CH2:8][OH:9])([CH3:7])[C:4]([OH:6])=[O:5])[OH:2].[CH2:10](O)[CH3:11]>>[CH2:1]([C:3]([CH2:8][OH:9])([CH3:7])[C:4]([O:6][CH2:10][CH3:11])=[O:5])[OH:2]

참가 물질

3

반응물 2

HCID 702EthanolHCID 78501Dimethylolpropionic acid

생성물 1

HCID 23370761Ethyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate

실험 절차

2,2-bis(methylol)propionic acid (bis-MPA) (22.1 g, 0.165 mol) was added in ethanol (150 mL) with Amberlyst-15 (6.8 g) and refluxed overnight. The resins were then filtered out and the filtrate was evaporated. Methylene chloride (200 mL) was added to the resulting viscous liquid to filter the unreacted reagent and by-products. The solution was dried over Mg504, filtered, and the solvent was removed in vacuo. Ethyl 2,2-bis(methylol)propionate was obtained as a clear and colorless liquid (21.1 g, 86% yield).

후처리

  1. temperaturerefluxed overnight
  2. filtrationThe resins were then filtered out
  3. customthe filtrate was evaporated
  4. additionMethylene chloride (200 mL) was added to the resulting viscous liquid
  5. filtrationto filter the unreacted reagent and by-products
  6. customThe solution was dried over Mg504
  7. filtrationfiltered
  8. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-1bf505e21da74291b496869102b38a9a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536291B2

연결된 노트

불러오는 중…