Methyl trifluoroacetate → 2,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide

반응식

[CH2:1]([NH2:4])[C:2]#[CH:3].[F:5][C:6]([F:12])([F:11])[C:7](OC)=[O:8]>>[CH2:1]([NH:4][C:7](=[O:8])[C:6]([F:12])([F:11])[F:5])[C:2]#[CH:3]

참가 물질

반응물 2

HCID 9893Methyl trifluoroacetate

HCID 239041Propargylamine

생성물 1

HCID 110948052,2,2-trifluoro-N-(prop-2-yn-1-yl)acetamide수율 87.4%

반응 조건

온도: 0 °C

실험 절차

Propargyl amine (4.00 g, 72.62 mmol, 1.00 equiv.) was added dropwise to methyl trifluoroacetate (11.16 g, 87.15 mmol, 1.20 equiv.) at 0° C. The reaction mixture was stirred at 0° C. for 2 h and then concentrated under reduced pressure to remove methanol. The product was purified by vacuum distillation yielding propargyltrifluoroacetamide as a colorless liquid (9.59 g, 87%). The structure was confirmed by 1H- and 19F-NMR.

후처리

concentrationconcentrated under reduced pressure
customto remove methanol
distillationThe product was purified by vacuum distillation

출처 및 근거

ORD 기록: ord-0c87ca0e49aa4225a4f05950478c040b
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536323B2

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