4-Bromoaniline → 1-(4-Bromoanilino)-3-phenyl-2-propanol

HRID 432338

반응식

HRID 432338 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[O:9]1[CH2:18][CH:10]1[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CO>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:18][CH:10]([OH:9])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 78074-BromoanilineHCID 948262-(Phenylmethyl)oxirane

생성물 1

HCID 223472001-(4-Bromoanilino)-3-phenyl-2-propanol수율 70.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-bromoaniline (1.75 g, 0.0102 mol) and 2,3-epoxy-propylbenzene (1.77 g, 0.0132 mol) in methanol (40 mL) was heated at reflux for 16 hours. The mixture was cooled to ambient temperature and concentrated under reduced pressure. The residue was purified by flash chromatography on silica using ethyl acetate/n-heptane (1:5) as mobile phase to yield 1-(4-bromoanilino)-3-phenyl-2-propanol (2.2 g, 0.00719 mol) as a colorless oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 hours
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by flash chromatography on silica

출처 및 근거

ORD 기록
ord-dc01332db9424d8487704a15843dc794
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660744B1

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