Potassium Carbonate → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

HRID 432568노트

반응식

HRID 432568 반응식
C([O:4][CH2:5][C:6]([CH3:20])([CH3:19])[CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[CH3:19][C:6]([CH3:20])([CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:10]=[CH:9]1)[CH2:5][OH:4]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 545188152,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

생성물 1

HCID 187597722,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate (20 mg) in methanol was added saturated solution of K2CO3 in metanol (1.5 mL) and the resulting solution was stirred at room temperature for 1 hour. MeOH was evaporated in vacuo and water was added followed by CH2Cl2. The aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dired over Na2SO4 and evaporated in vacuo to afford the title compound as a slightly yellow oil.

후처리

  1. customMeOH was evaporated in vacuo and water
  2. additionwas added
  3. extractionThe aqueous layer was extracted with CHCl3
  4. washthe combined organic layers were washed with brine
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-3abaf1aa7a594129a08f557797f95ef6
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664238B1

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