Triacetoxyperiodinane → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde

HRID 432573노트

반응식

HRID 432573 반응식
[CH3:1][C:2]([CH3:17])([CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[N:8]=[CH:7]1)[CH2:3][OH:4].CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH3:1][C:2]([CH3:17])([CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=2)[N:8]=[CH:7]1)[CH:3]=[O:4]

참가 물질

5

반응물 3

HCID 159087TriacetoxyperiodinaneHCID 516892Sodium BicarbonateHCID 187597722,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol

생성물 1

HCID 187597702,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propioaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propanol (11 mg) in CH2Cl2 was added Dess-Martin periodinane (41 mg) and the resulting solution was stirred at room temperature for 15 minutes. Saturated NaHCO3 was added, the aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dried over Na2SO4 and evaporated in vacuo to afford the title compound as a slightly yellow oil.

후처리

  1. extractionthe aqueous layer was extracted with CHCl3
  2. washthe combined organic layers were washed with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-324e5c4dc50846dbadca52ec4dc1eecf
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664238B1

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