2,6-Difluorophenol → 3,4-Bis(4-methoxyphenyl)-6-(2,6-difluorophenoxy)pyridazine

HRID 432625노트

반응식

HRID 432625 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12](Cl)=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[F:24][C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:26]=1[OH:32]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[N:11][C:12]([O:32][C:26]3[C:25]([F:24])=[CH:30][CH:29]=[CH:28][C:27]=3[F:31])=[CH:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 943922,6-DifluorophenolHCID 125680843,4-Bis(4-methoxyphenyl)-6-chloropyridazine

생성물 1

HCID 102238783,4-Bis(4-methoxyphenyl)-6-(2,6-difluorophenoxy)pyridazine

실험 절차

In a similar manner as in Example 2, 3,4-bis(4-methoxyphenyl)-6-chloropyridazine (200 mg, 0.613 mmol) and 2,6-difluorophenol were reacted as starting materials at 150° C. for 72 hours and post-treatment was then conducted, whereby the title compound was obtained as a colorless crystalline powder (101.0 mg, 39.3%). Melting point: 204.7-206.4° C. (chloroform-hexane).

후처리

  1. customat 150° C.
  2. customfor 72 hours

출처 및 근거

ORD 기록
ord-34d23524bbf34dc5a984ab3f16f5a99c
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664256B1

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