참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(3-Chloropropyl)morpholine | HCID 95834 | — |
| 반응물 | [2-(4-acetamidophenylsulfanyl)-7-hydroxy-quinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine | HCID 178418855 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178474284 | HCID 178474284 | — |
반응 단계
To a solution of [2-(4-acetamidophenylsulfanyl)-7-hydroxy-quinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine (32 mg, 7.87.10−5 mol) in DMF (1 mL) is added potassium carbonate (65 mg, 4.72.10−4 mol) and the reaction mixture is heated to 80° C. N-(3-chloropropyl)morpholine (39 mg, 2.36.10−4 mol) is then added, and the mixture is stirred at 80° C. for 4 hours, cooled to room temperature and the solvent is evaporated. The resulting residue is purified by flash chromatography to afford the desired [2-(4-acetamidophenylsulfanyl)-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06664247B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_12 |
|---|
| ORD ID | ord-3c24bbb2c65c42efb8c665ab3970b820 |
|---|
| 출처 메모 | uspto-grants-2003_12 |
|---|
