Benzyl chloroformate → 1-Benzyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

반응식

C(N1CCCC(C(OCC)=O)C1)(=O)C1C=CC=CC=1.Cl.[O:21]=[C:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH:23]1[C:28]([O:30][CH3:31])=[O:29].Cl[C:33]([O:35][CH2:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1)=[O:34]>>[CH2:36]([O:35][C:33]([N:25]1[CH2:26][CH2:27][C:22](=[O:21])[CH:23]([C:28]([O:30][CH3:31])=[O:29])[CH2:24]1)=[O:34])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

참가 물질

반응물 3

HCID 10387Benzyl chloroformate

HCID 2724028Methyl 4-oxopiperidine-3-carboxylate hydrochloride

HCID 3784394Ethyl 1-benzoyl-3-piperidinecarboxylate

생성물 1

HCID 157481361-Benzyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate

실험 절차

This compound may be prepared in the same manner as ethyl 1-benzoyl-3-piperidinecarboxylate, starting with commercially available methyl 4-oxo-3-piperidinecarboxylate hydrochloride, diisopropylethylaamine and commercially available benzyl chloroformate.

출처 및 근거

ORD 기록: ord-cb9b41f38a1848d28da03e74a9eacd49
출처 데이터셋: uspto-grants-2003_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06664271B1

반응 노트

불러오는 중…