Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2-Thienyl)Butyric Acid → (S)-ethyl 1-(2-thienylpropyl)-3-piperidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2-Thienyl)Butyric Acid | HCID 78386 | — |
| 반응물 | Ethyl (3S)-piperidine-3-carboxylate | HCID 187784 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | Ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate | HCID 12114708 | — |
| 생성물 | (S)-ethyl 1-(2-thienylpropyl)-3-piperidinecarboxylate | HCID 54206822 | — |
반응 단계
This reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with commercially available 4-(2-thienyl)butyric acid (280 μl; 1.93 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (367.7 mg; 1.92 mmol) and (S)-ethyl nipecotate (300 μl; 1.94 mmol). The crude product was purified by chromatography on silica eluting with 30% ethyl acetatel70% hexane to 40% ethyl acetate/60% hexane in a single step gradient, giving (S)-ethyl 1-(2-thienylpropyl)-3-piperidinecarboxylate (181.7 mg) as a colorless oil. MS m/z (positive ion) 411 (MH++Et3N; 40), 332 (M+Na+; 30), 310 (MH+; 100), 101 (Et3NH+; 30).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06664271B1 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-283ea38535cd40d29998bfed421b0407 |
| 출처 메모 | uspto-grants-2003_12 |