Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Phenylpropionic acid → Ethyl 1-(2-phenylpropanoyl)-3-piperidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Phenylpropionic acid | HCID 10296 | — |
| 반응물 | Ethyl (3S)-piperidine-3-carboxylate | HCID 187784 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | Ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate | HCID 12114708 | — |
| 생성물 | Ethyl 1-(2-phenylpropanoyl)-3-piperidinecarboxylate | HCID 53689184 | — |
반응 단계
This reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with commercially available 2-phenylpropionic acid (265 μl; 1.94 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (371.3 mg; 1.94 mmol) and (S)-ethyl nipecotate (300 μl; 1.94 mmol). Crude product was purified by chromatography on silica eluting with 25% ethyl acetate/75% hexane, giving (S)±ethyl 1-(2-phenylpropionyl)-3-piperidinecarboxylate (268.9 mg) as a colorless oil. MS m/z (positive ion) 290 (MH+; 100), 142 (55), 115 (50).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06664271B1 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-b0568fc3ff6648e6b1d62d8085f6f4e5 |
| 출처 메모 | uspto-grants-2003_12 |