Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → N,N-Dimethyl-3-piperidinecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | N,N-Dimethylnicotinamide | HCID 81444 | — |
| 반응물 | Ethyl 2-(piperidin-3-yl)acetate | HCID 2760464 | — |
| 촉매 | Platinum oxide (PtO) | HCID 82844 | — |
| 생성물 | N,N-Dimethyl-3-piperidinecarboxamide | HCID 18760276 | 38.4% |
반응 단계
This reaction was run in the same manner as ethyl 3-piperidinylacetate, starting with commercially available N,N-dimethylnicotinamide (10 g; 66.7 mmol) and platinum oxide (1.02 g; 4.49 mmol). Trifluoroacetic acid (5.1 ml; 66.2 mmol) was used in place of L(+) tartaric acid. Crude product was purified by distillation at approximately 150° C./10 torr, giving N,N-dimethyl-3-piperidinecarboxamide (4.0 g) as a colorless oil. MS m/z (positive ion) 157 (MH+: 100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06664271B1 |
| 출처 데이터셋 | uspto-grants-2003_12 |
| ORD ID | ord-18054757282c498b95f60d33afcae9e4 |
| 출처 메모 | uspto-grants-2003_12 |