Methylamine → (Ferrocenylmethyl)methylamine

HRID 432969

반응식

HRID 432969 반응식
[C-:1]1([CH:6]=O)[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH-:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.[Fe+2:13].[CH3:14][NH2:15].[BH4-].[Na+]>C1COCC1.CO>[CH3:14][NH:15][CH2:6][C-:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH-:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.[Fe+2:13]

참가 물질

6

반응물 3

HCID 6329MethylamineHCID 4311764Sodium borohydrideHCID 15184314Ferrocenecarboxyaldehyde

생성물 1

HCID 15912148(Ferrocenylmethyl)methylamine수율 86.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of ferrocenecarboxaldehyde (700 mg, 3.27 mmol) and methylamine (2.0M in THF) (5.0 ml, 10.0 mmol) in THF (25 ml) and methanol (30 ml) was stirred at room temperature for 15 h under a nitrogen atmosphere. Sodium borohydride (371 mg, 9.81 mmol) was added to the solution and it was stirred at room temperature for 1 h. The solvent was removed out under reduced pressure and the residue dissolved in chloroform. The chloroform was washed with water, dried over magnesium sulphate. The solvent was removed under reduced pressure to yield a brown oil (647 mg, 86%).

후처리

  1. customThe solvent was removed out under reduced pressure
  2. dissolutionthe residue dissolved in chloroform
  3. washThe chloroform was washed with water
  4. dry with materialdried over magnesium sulphate
  5. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-b94a4a2f3e4448a68a13a414c8786a03
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664407B2

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