Water → 1-Iodo-4-methyl-4-nitro-pentane

HRID 432991노트

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HRID 432991 반응식
CS(O[CH2:6][CH2:7][CH2:8][C:9]([CH3:14])([N+:11]([O-:13])=[O:12])[CH3:10])(=O)=O.[I-:15].[Na+].O>CC(C)=O>[CH3:10][C:9]([N+:11]([O-:13])=[O:12])([CH3:14])[CH2:8][CH2:7][CH2:6][I:15]

참가 물질

5

반응물 3

HCID 962WaterHCID 5238Sodium IodideHCID 130471214-Methyl-4-nitropentyl methanesulfonate

생성물 1

HCID 99430631-Iodo-4-methyl-4-nitro-pentane수율 99.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Methyl-4-nitropentanol methanesulfonate (3.38 g, 15 mmol) was dissolved in acetone (50 ml) and sodium iodide (8.7 g, 58 mmol) was added. The mixture was stirred overnight. Water (20 ml) was added and acetone was evaporated by concentration under reduced pressure. The residue was extracted with ethyl acetate (50 ml). The extract was washed with 5% aqueous sodium thiosulfate solution (20 ml) and saturated brine (20 ml), and ethyl acetate was evaporated by concentration under reduced pressure to give the objective compound (3.84 g, yield 99.6%).

후처리

  1. customacetone was evaporated by concentration under reduced pressure
  2. extractionThe residue was extracted with ethyl acetate (50 ml)
  3. washThe extract was washed with 5% aqueous sodium thiosulfate solution (20 ml) and saturated brine (20 ml), and ethyl acetate
  4. customwas evaporated by concentration under reduced pressure

출처 및 근거

ORD 기록
ord-084abec90d204b638ecc24bdcab17c62
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664412B2

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