Dimethylamine → Octanamide

반응식

C[NH:2]C.[C:4](Cl)(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]>>[C:4]([NH2:2])(=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 8124Octanoyl chloride

생성물 1

HCID 69414Octanamide

반응 조건

온도: 10 °C

실험 절차

135.03 g of Dimethyl Amine solution is charged at room temperature and cooled to 10±2° C., then Octanoyl Chloride obtained in EXAMPLE 4 is charged at 8 to 12° C. over a period of 2 hours, and the reaction mixture is stirred at 10 to 15° C. for 30 minutes and then stirred at room temperature for 1 hour and the upper organic layer is separated from lower aqueous layer and 29.80 g of Sodium Chloride (20% solution) is added to the organic layer. This organic layer is washed and 9.94 g of Sodium Sulphate is added to the organic layer to take up water, and the mixture is filtered to obtain crude Octanamide.

후처리

stirringstirred at room temperature for 1 hour
customthe upper organic layer is separated from lower aqueous layer and 29.80 g of Sodium Chloride (20% solution)
additionis added to the organic layer
washThis organic layer is washed
addition9.94 g of Sodium Sulphate is added to the organic layer
filtrationthe mixture is filtered

출처 및 근거

ORD 기록: ord-4a453be5931640edaf4b3ab0c2ecdb2b
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536355B2

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