Sulfuric Acid → 3-Benzylcyclopent-2-en-1-one

HRID 433093

반응식

HRID 433093 반응식
C(O[C:4]1[CH2:8][CH2:7][C:6](=[O:9])[CH:5]=1)C.[CH2:10]([Mg]Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.OS(O)(=O)=O>C1COCC1>[CH2:10]([C:4]1[CH2:8][CH2:7][C:6](=[O:9])[CH:5]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 897773-Ethoxycyclopent-2-en-1-oneHCID 178418336HCID 178418336, 화합물

생성물 1

HCID 118299173-Benzylcyclopent-2-en-1-one수율 35%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 3-ethoxy-2-cyclopenten-1-one (5 g, 0.89 mol) in THF (70 mL) was added at room temperature to a solution of 2M benzyl magnesium chloride (800 mL) under N2 and stirred for 6 h. The resulting mixture was poured into a solution of 30% H2SO4 and stirred for 5 h. The resulting organic layer was separated, and the aqueous layer was extracted with several portions of ether. The combined organic layer was dried (MgSO4), and concentrated in vacuo to give the title compound (3.1 g, 35%) as a colorless oil.

후처리

  1. stirringstirred for 5 h
  2. customThe resulting organic layer was separated
  3. extractionthe aqueous layer was extracted with several portions of ether
  4. dry with materialThe combined organic layer was dried (MgSO4)
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-c4616eef68014509b4438c12376df18b
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667309B2

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